5 edition of Interactions Between the Stroma and Thyroid Epithelial Cells of Normal and Malignant Origin found in the catalog.
Interactions Between the Stroma and Thyroid Epithelial Cells of Normal and Malignant Origin
by Uppsala Universitet
Written in English
|Series||Comprehensive Summaries of Uppsala Dissertations, 861|
|The Physical Object|
Surface epithelial stromal tumors, the most common neoplasms of the ovary, encompass five distinct subtypes, namely, serous, mucinous, endometrioid, clear cell and transitional cell along with. Thyroid Follicular Epithelial Cell Lesions Los Angeles Society of Pathologists The 13th Annual Current Topics in Pathology Janu Bruce M. Wenig, M.D. Continuum Health Partners Dept. of Pathology & Laboratory Medicine New York, NY.
Syndecan-1 (CD) is a transmembrane proteoglycan known to be expressed in various normal and malignant tissues. It is of interest because of a possible prognostic role of differential expression in tumors and its role as a target for indatuximab, a monoclonal antibody coupled with a cytotoxic agent. To comprehensively analyze CD in normal and neoplastic tissues, we used tissue microarrays Author: Simon Kind, Christina Merenkow, Franziska Büscheck, Katharina Möller, David Dum, Viktoria Chirico, A. stroma. CELLS OF THE STROMA Cells within the stroma include ﬁbroblasts, vascular, glial, smooth muscle, epithelial, and fat cells, and cells of the immune system. The most widely studied to date are the ﬁbroblasts, immune cells, and the vascular cells, which we will focus on in this review. Fibroblasts Fibroblasts within normal tissue. In.
malignant cells, while the adaptive immune system rather controls the tumour progression. However, tumours can evade the host immune system via various mechanisms. They shed surface antigens and down-regu-late the expression of molecules necessary for interaction with immune cells. They also produce and release factorsCited by: Pathology Test 2. STUDY. PLAY. Neoplasms • New and abnormal formation of tissue • Poorly differentiated- have cells that are difficult to recognize as their cell of origin. Degree of Differentiation • Malignant growth of epithelial cells/ skin cells • Flat, scaly epithelial cells.
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Endocrine and locally produced factors as well as interactions between epithelial cells and the stroma important in the control of growth and function of the thyroid gland. In this study, the effects of, and mechanism(s) for, such cross-talk under some normal and pathological conditions were investigated.
In this study, a co-culture model containing epithelial and stromal cells was used to investigate the interactions of these cells in macromastia. Epithelial cell proliferation and branching morphogenesis were measured to assess the effect of macromastic stromal cells on epithelial by: 8.
Interactions between the stroma and thyroid epithelial cells of normal and malignant origin Dahlman, Thérèse Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
The interaction between stroma and epithelium can either result in a protective outcome or in malignant transformation. So, epithelial stem cell malignant transformation is Cited by: 4. Interactions between stroma and epithelia in the normal and malignant prostatic microenvironment involve a number of soluble factors and their receptors.
Soluble factors act in paracrine fashion by binding to their respective by: The biological and clinical significance of stromal-epithelial interactions in breast cancer Article (PDF Available) in Pathology 49(2) December with 84 Reads How we measure 'reads'. Stromal–epithelial cell interactions and alteration of branching morphogenesis in macromastic mammary Available via license: CC BY Content may be subject to copyright.
Tumor-stroma interactions at different stages of keratinocyte transformation To determine the alterations that occur in epithelial- stromal interactions during the transformation process in pre-malignant and malignant epithelial tumors, a family of cell lines of transformed human keratinocytes was by: Concluding Remarks In the foregoing sections various modes of interaction between malignant cells and stroma have been described: Malignant cells have been shown to produce various lytic enzymes, which attack the stroma or to induce fibroblasts to synthesize collagenolytic, elastolytic, and glycosaminoglycan-degrading enzymes (Sections II,B-F J,K).Cited by: Thyroid nodules can be hyperplastic benign adenomas or malignant lesions, and can be derived from thyroid follicular epithelial cells or C cells ().Cancers that arise in the thyroid.
The leading role of epithelial-stromal dialogue in the development of the mammary gland has been well recognized, but accumulating evidence has demonstrated that in breast cancer altered interactions occurring between epithelial malignant cells and the associated fibroblasts play a major part in tumor development, growth and progression –.Cited by: The interaction between HA and cells is mediated by different cell surface receptors, among which CD44 is the most prominent one on melanoma cells.
Furthermore, CD44 interacts with a wide variety of different proteins, including osteopontin, collagen, fibronectin, growth factors, cytokines, and chemokines, as well as metalloproteinases.
Tumor Stroma in Anaplastic Thyroid Carcinoma Interstitial Collagen and Cancers are classified according to the tissue and cell type of origin. Cancers from epithelial cells are termed carcinomas and mesenchymal malignancies are termed matrix (ECM) and carcinoma cells – stroma interactions provide reciprocal influences, which result in.
It is notable that, although the average intensity for each category of normal and malignant endometrium is shown in Fig. 6(A) and 6(B), there was a wide range of patient variability of PEDF immunostaining for nearly all categories of patient tissues for both the epithelial and stromal cells of the endometrium; the epithelial cells show the Cited by: 6.
The study of cancer biology has mainly focused on malignant epithelial cancer cells, although tumors also contain a stromal compartment, which is composed of stem cells, tumor-associated fibroblasts (TAFs), endothelial cells, immune cells, adipocytes, cytokines, and various types of macromolecules comprising the extracellular matrix (ECM).
The tumor stroma develops gradually in response to the Cited by: There is strong association between inflammatory processes and their main metabolic mediators, such as leptin, adiponectin secretion, and low/high-density lipoproteins, with the cancer risk and aggressive behavior of solid tumors.
In this scenario, cancer cells (CCs) and cancer stem cells (CSCs) have important roles. These cellular populations, which come from differentiated cells and Cited by: 4. Solid tumors have a distinct structure that mimics that of normal tissues and comprises two distinct but interdependent compartments: the parenchyma (neoplastic cells) and the stroma that the neoplastic cells induce and in which they are dispersed.
2–4 In many tumors, including those of epithelial cell origin, a basal lamina separates clumps of tumor cells from stroma. However, the basal lamina is often incomplete, especially at points of tumor Cited by: 5.
Both normal and malignant epithelial ovarian cells also produce IL-1, although activated immune cells in the stroma remain the major source of IL Constitutive production of IL-1 β by ovarian carcinoma cells [ 95 ] enhances their invasion capacities by increasing expression of MMP-1 [ 36 ] and stimulating production of proangiogenic factors such as vascular endothelial growth factor (VEGF) [ Cited by: 6.
Genes and gene sets induced in the tumor stroma. (a) Hierarchical cluster analysis of tumor cell, tumor stroma and normal stroma samples.A total of genes was differentially expressed between Cited by: Interactions between epithelial and stromal cells are evident in the oviduct (Umezu and Tomooka, ) as well as in the uterus, where they have been extensively studied in human models for.
Carcinoma cells, like normal epithelial cells, live in a complex microenvironment that includes the extracellular matrix (ECM), diffusible growth factors and cytokines, and a variety of non.A carcinoma is a malignant tumor of epithelial origin. It is characterized by a marked proliferation of epithelium with infiltration into the surrounding tissues.
The epithelium is arranged atypically in a supporting framework made up of adult connective tissue.Galectin-3, a beta-galactoside binding lectin, is highly expressed in thyroid carcinomas of follicular cell origin, whereas neither benign thyroid adenomas nor normal thyroid tissues express.